CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

CD1 molecules are glycosylated heterodimers composed of a heavy chain polypeptide non-covalently associated with β2-microglobulin (β2m). Group I and II CD1 proteins are mainly …

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Dec 1, 2007 · This Review describes the journey taken by the MHC-class-I-like CD1 molecules, detailing their assembly, intracellular trafficking and loading with lipid antigens.

Here, we explain CD1-lipid-TCR interactions, highlight two recent examples of antigen recognition that diverge from accepted models, and summarize recent studies of disease-focused work in …

Jun 13, 2025 · CD1 molecules are a family of glycoproteins that play a crucial role in the immune system, particularly in the presentation of lipid antigens to T cells. In this section, we will …

CD1 is structurally and functionally similar to MHC class I and II molecules; however, CD1 presents lipids rather than polypeptides on antigen presenting cells. CD1 has also evolved a …

Whereas CD1 proteins were thought solely to influence T-cell responses through display of amphipathic lipids, recent studies emphasize the role of direct contacts between the T-cell …

Sep 11, 2023 · In this review, we discuss the CD1-mediated antigen presentation system and its roles in mucosal tissue immunity.

Aug 22, 2024 · Each CD1 isoform was found to have unique lipid species, suggesting some distinct roles in lipid presentation and immune responses. These findings contribute to our …