“This is a paradigm shift,” says Donn Van Deren, PhD, postdoctoral research fellow at the University of Pennsylvania, who conducted the research while working in human genetics at the University of ...

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function ...

Findings reveal that microglia may serve as a potential therapeutic target for the treatment of hyponatremia-related neurological dysfunctions and osmotic demyelination syndrome (ODS) Low serum sodium ...

Move over protein plaques; a groundbreaking study reveals that fat-clogged immune cells are the real culprits behind brain ...

During most eye infections or injuries, neutrophils, immune cells found in the blood, are usually the first line of defense. However, researchers at the Flaum Eye Institute and Del Monte Institute for ...

Major depressive disorder affects hundreds of millions worldwide, but a key to understanding its origins may lie in the brain’s immune system. New findings spotlight astrocytes—previously overshadowed ...

Immune-regulating brain cells known as microglia are known to play a role in the progression of Alzheimer’s disease (AD). Investigators at Brigham and Women’s Hospital studying the genetics of ...

An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development. By incorporating ...

A new study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer's pathology in other ways. A rare but potent genetic ...

Nestled within the plasma membrane, γ-secretase trims the ends off membrane proteins. Among its 150 known substrates, none is more famous than APP. The protease chews APPs transmembrane domain to spit ...