Excitotoxicity is the pathological process by which neurons are damaged and killed by the overactivations of receptors for the excitatory neurotransmitter glutamate, such as the NMDA receptor and AMPA ...

Figure 1: Clinical course of adoptive transfer EAE: Effect of treatment with NBQX. Dephosphorylation of NF-H has provided a useful quantitative molecular marker for the severity of EAE, emphasizing ...

A new study has prompted scientists to reconsider a once-popular yet controversial idea in stroke research. Neuroscientists believed that, in the aftermath of a stroke, calming overexcited neurons ...

For decades, the duality of NMDA glutamate receptors has perplexed researchers. Essential players in synaptic activity, plasticity, and learning, these receptors can also trigger a toxic intraneuronal ...

One hypothesis for the death of motor neurons in amyotrophic lateral sclerosis (ALS) is that the neurons become hyperexcited, firing overtime and ultimately being poisoned by their own activity (Rao ...

Neuroprotection refers to mechanisms and strategies that aim to protect the nervous system from injury and damage. This is especially important for those with certain neurological diseases. Current ...

In multiple sclerosis (MS), a demyelinating disorder, autoimmunity is generally considered the primary underlying pathophysiological cause. Therefore, developing treatments for MS has traditionally ...